Vanguard Plus 5 L4 by Zoetis

Vanguard Plus 5 L4 (formerly Vanguard DAPP+L4) is a multivalent veterinary vaccine formulated to immunize healthy dogs against major viral and bacterial pathogens. It combines modified-live viruses for canine distemper (CD), adenovirus type 1 (hepatitis, CAV‑1), adenovirus type 2 (respiratory, CAV‑2), parainfluenza (CPI), and parvovirus (CPV), with inactivated bacterins against four Leptospira serovars: canicola, grippotyphosa, icterohaemorrhagiae, and pomona. The vaccine evokes robust immune responses, including CPV titers capable of overcoming maternal antibodies.

Usage:

• Target Species: Healthy dogs (≥ 6 weeks old)

• Vaccination Schedule:

  • Primary series: 2 doses, 2–3 weeks apart (a third dose is recommended if initiated before 9 weeks to avoid maternal antibody interference) 

  • Revaccination: Annually with one 1 mL dose, tailored to lifestyle risk.

• Administration:

  • Reconstitute freeze-dried vaccine with sterile diluent supplied, mix well, and administer 1 mL subcutaneously (or intramuscularly)

Features and Benefits:

• Broad, 9-in-1 protection: Against CD, CAV‑1/2, CPI, CPV, plus 4 Leptospira serovars 

• High CPV immunogenicity: Generates protective titers even with maternal antibodies.

• Convenient single-dose formulation: Simplifies vaccination protocols.

• Annual booster compliance: Supports regular immunity maintenance.

Precautions:

• Keep refrigerated at 2–7 °C; do not freeze; avoid sunlight and heat.

• Use immediately after reconstitution; discard contents after use .

• Contains gentamicin as preservative; avoid use in pregnant bitches.

• In case of hypersensitivity reactions (e.g., anaphylaxis), treat with epinephrine.

• Adverse reactions are rare but may include mild fever or lethargy.